General model — model • assemblerr

This function creates the basis for a general pharmacometric model, a flexible but verbose model type.

model()

Value

A general pharmacometric model

Details

The function creates the foundation for a general pharmacometric model to which different building blocks can be added. The following building blocks are relevant for this model type:

Parameters: prm_log_normal, prm_logit_normal, prm_no_var, prm_normal
Observations: obs_additive, obs_combined, obs_proportional
Algebraic relationships: algebraic
Compartments: compartment
Flows: flow
Input variables: input_variable, dataset

The more specialized pk_model() is converted to a general model during the rendering process.

Examples

m <- model() +
    input_variable("dose") +
    prm_log_normal("emax") +
    prm_log_normal("ed50") +
    obs_additive(eff~emax*dose/(ed50+dose))
render(m)
#> $PROBLEM
#> $INPUT DOSE ID DV
#> $DATA data.csv IGNORE=@
#> $PRED
#> EMAX = THETA(1) * EXP(ETA(1))
#> ED50 = THETA(2) * EXP(ETA(2))
#> EFF = EMAX * DOSE/(ED50 + DOSE)
#> Y = EFF + EPS(1)
#> $ESTIMATION METHOD=COND MAXEVAL=999999 
#> $THETA (0, 1, Inf) ; POP_EMAX
#> $THETA (0, 1, Inf) ; POP_ED50
#> $OMEGA 0.1 ; IIV_EMAX
#> $OMEGA 0.1 ; IIV_ED50
#> $SIGMA 1; RUV_ADD