assemblerr

assemblerr is an R package to construct pharmacometric models by combining pre-defined model components. It’s intended to simplify the specification of complex pharmacometric models and provide a mechanism to generate models in an automatic way. With assemblerr, models are specified using R code and then converted to a NONMEM control stream.

Installation

You can install the latest CRAN version assemblerr using:

install.packages("assemblerr")

Quick start

Load assemblerr

Build a simple model

m <- model() +
  input_variable("dose") +
  prm_log_normal("emax", median = 10, var_log = 0.09) +
  prm_log_normal("ed50", median = 50, var_log = 0.09) +
  algebraic(effect~emax*dose/(ed50 + dose)) +
  obs_additive(~effect, var_add = 1)

Generate NONMEM code

render(m) 
#> $PROBLEM
#> $INPUT DOSE ID DV
#> $DATA data.csv IGNORE=@
#> $PRED
#> EMAX = THETA(1) * EXP(ETA(1))
#> ED50 = THETA(2) * EXP(ETA(2))
#> EFFECT = EMAX * DOSE/(ED50 + DOSE)
#> Y = EFFECT + EPS(1)
#> $ESTIMATION METHOD=COND MAXEVAL=999999 
#> $THETA (0, 10, Inf) ; POP_EMAX
#> $THETA (0, 50, Inf) ; POP_ED50
#> $OMEGA 0.09 ; IIV_EMAX
#> $OMEGA 0.09 ; IIV_ED50
#> $SIGMA 1; RUV_ADD

Learning more

The best place to learn how to use assemblerr is the vignette “Getting Started”. It provides an overview of the functionality in assemblerr and helps you building your own models. A simple way to find it is using the vignette() function in R:

vignette("getting-started", package = "assemblerr")