Perl-speaks-NONMEMPerl-speaks-NONMEM (PsN) is a collection of Perl modules and programs aiding in the development of non-linear mixed effect models using NONMEM. The functionality ranges from solutions to simpler tasks such as parameter estimate extraction from output files, data file sub setting and resampling, to advanced computer-intensive statistical methods. PsN includes stand-alone tools for the end-user as well as development libraries for method developers.
Use the top menu for information on how to Download and Install PsN. You can read about the different parts of PsN under Documentation and also learn about Known Bugs, how to submit a new bug and how to become a part of the PsN mailing list.
Latest release PsN 4.7.0(Released on May 23rd 2017).
New features in this version include;
- Major extensions to simeval, a tool for simulation-evaluation diagnostics for outlier detection.
- Updates to frem, a tool for full random effects modelling for covariate building.
- A new tool, resmod, used for evaluating different residual models, the addition of support for R Markdown when using rplots greatly facilitating the automatic creation of reports and support for NONMEM 7.4.1.
©2018 by Mats Karlsson, Andrew Hooker, Rikard Nordgren and Svetlana Freiberga. All rights reserved.
©2016-2017 by Mats Karlsson, Andrew Hooker, Rikard Nordgren, Kajsa Harling and Svetlana Freiberga.
©2013-2015 by Mats Karlsson, Andrew Hooker, Rikard Nordgren and Kajsa Harling.
©2008-2012 by Mats Karlsson, Niclas Jonsson, Andrew Hooker and Kajsa Harling.
©2006-2007 by Lars Lindbom.
©2000-2005 by Lars Lindbom and Niclas Jonsson.
Perl-speaks-NONMEM is a free and open source software: you can redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation, either version 2 of the License, or (at your option) any later version.
PsN was originally developed by Niclas Jonsson and continued by Lars Lindbom for his doctoral thesis.
Lead developer for PsN between 2008 and 2016 was Kajsa Harling.
Additional implementation has been done by Pontus Pihlgren, Jakob Ribbing, Kristin Karlsson, Maria Kjellsson and Joakim Nyberg.
Additional contributions by Radojka Savic, Paul Baverel, Martin Bergstrand, Elodie Plan, Yasunori Aoki, William Denney and many more.
References: Lindbom L, Pihlgren P, Jonsson EN. PsN-Toolkit--a collection of computer intensive statistical methods for non-linear mixed effect modeling using NONMEM. Comput Methods Programs Biomed. 2005 Sep;79(3):241-57.
Lindbom L, Ribbing J, Jonsson EN. Perl-speaks-NONMEM (PsN)--a Perl module for NONMEM related programming. Comput Methods Programs Biomed. 2004 Aug;75(2):85-94.
Acknowledgements: PsN was developed in parts with funding from the DDMoRe and IDeAl projects. NONMEM® is a registered trademark of ICON plc. The Perl camel logo is a registered trademark of O'Reilly Media, Inc. and is used with permission. All logos and trademarks in this site are property of their respective owners.